While the idea of running InDesign from a USB stick without an installation process is appealing, you should be aware of the following:

: Adobe shut down the CS3 activation servers in 2017. Even with a legitimate serial number, it is nearly impossible to activate old Creative Suite software on new machines. Why People Still Search for InDesign CS3

: Unofficial "portable" versions are often hosted on third-party sites and can be bundled with malware , spyware , or keyloggers .