Always connect a diode and a capacitor between the VCC, VB, and VS pins. Without a proper virtual bootstrap capacitor, the high-side MOSFET will not turn on.
Unzip the downloaded folder on your desktop. ir2110 proteus library
Keep your PWM switching frequency within realistic limits (typically under 100kHz for basic Proteus simulations) to avoid software lag or simulation crashes. Always connect a diode and a capacitor between